Description
Test Description:
| CODE: | ATG |
| UNITS: | IU/mL |
| TECHNOLOGY: | C.L.I.A |
| FASTING TYPE: | NON FASTING |
| SAMPLE TYPE: | SERUM |
| VOLUME: | 1ml |
| NORMAL RANGE: | Negative : < 115 Positive : > 115 |
Clinical Significance:
It is found in autoimmune thyroid disorders like Hashimoto’s thyroiditis. Grave’s disease and also thyroid carcinoma. Occasionally used to distinguish between Grave’s diseases from toxic multinodular goiter when physical findings are not diagnostic. Antithyroglobulin antibodies are specific antibodies produced by the immune system that bind to thyroglobulin. They may be present in a number of different disease states that affect the thyroid gland. It is important to realize that a patient may develop antithyroglobulin antibodies at any time in the course of treatment or follow-up. Any time that thyroglobulin is measured; the blood sample should be tested for antithyroglobulin antibodies to determine whether the measurement of thyroglobulin is valid.
Clinical applications:
- Used in etiology of the thyroid function disorder
- In conjunction with AM A these antibody tests are used by many thyroidologists to confirm or rule out the involvement of autoimmune process in the “Observed Hyperthyroidism”
Remarks
- Though EIA and RIA methods are available, the reproducibility and reliability of the test done with HA (hemagglutination) is far more satisfying due to multiple dilution option.
- Levels may be as high as 1:12802 before treatment.
Note:
- ATA: means Anti-thyroid antibodies. This includes both ATG and AMA
- Thyroid peroxidase antibody means antimicrosomal antibody (AMA)
- Treatment for thyroid dysfunction may not reduce the titers of ATG and AMA
- Too high titers for too long periods suggest the possibility of Permanent failure of thyroid
- If a hyperthyroid patient displays increased levels of ATG and or AMA it is likely sooner or later the patient may become hypothyroid
